Analysis Of Antioxidant Activity Of A Combination Of Turmeric Rhyme Extract (Curcuma Domestica Val.) And Katu Leaves (Sauropus Androgynus) As Additional Therapy For Type 2 Dm
DOI:
https://doi.org/10.62872/bv7wk486Keywords:
Antioxidants, DPPH, Diabetes Mellitus Type 2, Sauropus androgynus, Curcuma domestica ValAbstract
The importance of reform in the health sector will be ammunition in realizing the Society 5.0 era. In Indonesia, there is currently an epidemiological transition which is causing a shift in disease patterns, namely an increase in degenerative diseases, one of which is diabetes mellitus. It is hoped that the creation of an innovative herbal drink combining turmeric rhizome and katuk leaves will be an additional therapy for people with type 2 diabetes mellitus. The aim of this research is to analyze antioxidant activity using the DPPH method. The research was carried out by analyzing antioxidant activity based on the IC50 value. The samples in this study were turmeric rhizome extract (Curcuma domestica Val.) and katuk leaf extract (Sauropus androgynus). There were 3 test samples, namely turmeric rhizome extract (sample 1), katuk leaf extract (sample 2) and a combination extract of turmeric rhizome and katuk leaves (sample 3). Based on the research, IC50 values were obtained from three formulations, namely sample 1 of 40 ppm, sample 2 of 40 ppm and sample 3 of 30 ppm. These results were also compared with the standard antioxidant activity of vitamin C used at 20 ppm. Based on the three samples with antioxidant activity results, sample 3 has the best antioxidant activity compared to samples 1 and 2 so that it can inhibit free radical
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Abadi, E., Tahiruddin, dan Narmawan. 2020. Hubungan Kualitas Tidur Terhadap Kadar Glukosa Darah Pasien Diabetes Melitus Tipe 2 Lispin. Jurnal Kesehatan Masyarakat Celebes. 1(3): 1–7.
Adli, Farhan Kamali. 2020. Diabetes Melitus Gestasional: Diagnosis Dan Faktor Risiko. Jurnal Bagus. 2(01): 402–406.
Anies. 2018. Penyakit Degeneratif : Mencegah dan Mengatasi Penyakit Degeneratif dengan Perilaku dan Pola Hidup Modern yang Sehat. Yogyakarta: Ar-Ruzz Media
Azizah, S. N., dan Qomariyah, N. 2021. Aktivitas Antidiabetik Ekstrak Anacardium Occidentale Terhadap Kadar Glukosa Dan Pemulihan Luka Ulkus Diabetikum Pada Mencit Antidiabetic Activity Of Anacardium Occidentale Extract On Glucose Levels And Recovery Diabetic Ulcers In Mice. Lenterabio. 11(2): 15–25.
Dehpour, A.A., Ebrahimzadeh, M.A., Fazel, N.S., dan Mohammad, N.S. 2009. Antioxidant Activity of Methanol Extract of Ferula assafoetida and Its Essential Oil Composition. Grasas Aceites. 60 (4): 405-412.
Dinis, T.C., Maderia, V.M., dan Almeida, L.M. 1994. Action of Phenolic Derivates (Acetoaminophen, Salycilate and 5-Aminosalycilate) as Inhibitors of Membrane Lipid Peroxidation and as Peroxyl Radical Scavengers. Archives of Biochemistry and Biophysics. 315: 161–169.
Fakriah, Kurniasih, E., Adriana, dan Rusydi. 2019. Sosialisasi Bahaya Radikal Bebas Dan Fungsi Antioksidan Alami Bagi Kesehatan. Jurnal Vokasi, 3(1): 1-7. ISSN : 2548-9410 (Cetak) | ISSN : 2548-4117 (Online).
Fikri, F., dan Purnama, M. T. E. 2020. Pharmacology And Phytochemistry Overview On Sauropus androgynous. Systematic Reviews In Pharmacy. 11(6): 124–128.
Kumar, SK. Gousia, Anupama, M. And J. Naveena Lavanya Latha. 2013. A Review On Phytochemical Constituents And Biological. International Journal of Pharmacy and Pharmaceutical Science Research. 3(4): 136-139.
Kemenkes RI. 2020. Tetap Produktif, Cegah, dan Atasi Diabetes Melitus. Infodatin, 1–6. Tersedia pada https://pusdatin.kemkes.go.id/folder/view/01/
structurepublikasi-pusdatin-info-datin.html
Lestari, Zulkarnain, dan Sijid, S. A. 2021. Diabetes Melitus: Review Etiologi, Patofisiologi, Gejala, Penyebab, Cara Pemeriksaan, Cara Pengobatan Dan Cara Pencegahan. Uin Alauddin Makassar. 237–241.
Muadifah A., Putri, A.E., Latifah, N., 2019, Aktivitas Gel Ekstrak Rimpang Kunyit (Curcuma domestica Val.) terhadap Bakteri Staphylococcus aureus, Jurnal SainHealth, 3 (1): 45-53
Ozougwu, O. 2013. The pathogenesis and pathophysiology of type 1 and type 2 diabetes melitus. Journal of Physiology and Pathophysiology, 4(4): 46–57.
Petersmann, A., Nauck, M., Müller-Wieland, D., Kerner, W., Müller, U. A., Landgraf, R., Freckmann, G., & Heinemann, L. 2018. Definition, Classification And Diagnostics Of Diabetes Melitus. Journal Of Laboratory Medicine. 42(3): 73–79.
Pranata, S. T. 2014. Herbal TOGA (Tanaman Obat Keluarga). Yogyakarta: Aksara Sukses.
Proklamasiningsih, E., Budisantoso, I., dan Maula, I. 2019. Pertumbuhan Dan Kandungan Polifenol Tanaman Katuk (Sauropus androgynus (L.) Merr) Pada Media Tanam Dengan Pemberian Asam Humat Growth And Polyphenol Content Of Katuk Plant (Sauropus androgynus (L.) Merr) In The Growing Medium That Containing Humic Acid). Journal Of Biology, 12(1): 96–102.
Sandra, D., Argueta, E., Wacher, N. H., Silva, M., Valdez, L., Cruz, M., Gómez-Díaz, R. A., Casas-Saavedra, L.P., De Orientación, R., Salud México, S. De, Virtual, D., Social, I. M. Del S., Mediavilla, J., Fernández, M., Nocito, A., Moreno, A., Barrera, F., Simarro, F., Jiménez, S., dan Faizi, M.F. 2016. Efek Imunostimulan Fraksi Daun Katuk (Sauropus androgynus L. Merr.) Terhadap Aktivitas Dan Kapasitas Fagositosis Makrofag Pada Mencit Jantan (Mus Musculus). Jf Fik Uinam. 152(3): 28.
Suherman, Musnaini, Wijoyo H., Indrawan, I. 2020. Industry 4.0 Vs Society 5.0. Banyumas: Penerbit Pena Persada.
Suprihatin, T., Rahayu, S., Rifa'i, M., & Widyarti, S. 2020. Senyawa pada Serbuk Rimpang Kunyit (Curcuma longa L.) yang Berpotensi sebagai Antioksidan. Buletin Anatomi dan Fisiologi, 5(1): 35-42.
Voight, R. 1994. Buku Pelajaran Teknologi Farmasi. Yogyakarta: Gadjah Mada University Press.
Windono,T., Soediman, S., Yudawati, U., Ermawati, E., Srielita, A., dan Erowati, T.I. 2001. Uji Peredam Radikal Bebas Terhadap 1,1-Diphenyl-2- picrylhydrazyl (DPPH) dari Ekstrak Kulit Buah dan Biji Anggur (Vitis vinifera L.) Probolinggo Biru dan Bali. Artocarpus. 1 (1): 34- 43.
Yaribeygi, H., Farrokhi, F. R., Butler, A. E., & Sahebkar, A. 2018. Insulin resistance: Review of the underlying molecular mechanisms. Journal of Cellular Physiology.
Yunita, O., Wijayanto, D. V., Hapsari, A. D., Sari, M. L. W. W., & Krisnawan, A. H. 2021. Characterization Of Green Pigment From Sauropus androgynus Shoot Cultures. Mpi (Media Pharmaceutica Indonesiana). 3(3): 128-137.
Zanaria, R., Kamaluddin, M., dan Theodorus, T. 2019. Efektivitas Ekstrak Etanol Daun Salam (Eugenia Polyantha) Terhadap Glut 4 Di Jaringan Adiposa Dan Kadar Gula Darah Puasa Pada Tikus Putih Jantan. Biomedical Journal Of Indonesia. 3(3). 145–153.
Zhang, B., Cheng, J., Zhang, C., Bai, Y., Liu, W., Li, W., Zhang, J. 2020. Sauropus androgynus L. Merr.-A phytochemical, pharmacological and toxicological review. Journal of Ethnopharmacology
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