Effectiveness of Antibiotic Use in the Prevention and Treatment of Respiratory Tract Infections
DOI:
https://doi.org/10.62872/6tqjqh98Keywords:
Antibiotic, Prevention and Treatment, Respiratory Tract InfectionsAbstract
This study aims to analyze the effectiveness of the use of antibiotics in the prevention and treatment of respiratory tract infections. This study uses the Systematic Literature Review (SLR) method. There are three stages carried out in mapping the effectiveness of antibiotic use in the prevention and treatment of respiratory tract infections, namely: 1) harvesting data, 2) screening data, and 3) Data Analysis and Visualization. This study uses a database from Scopus with scientific journals as many as 9 articles from the range of 2021 to 2024. The effectiveness of antibiotic use in the prevention and treatment of respiratory tract infections is influenced by a variety of factors, including patient adherence, duration of therapy, and vaccine availability and use. Excessive or improper use of antibiotics can increase bacterial resistance, so more sustainable strategies, such as vaccination and stricter antibiotic use policies, are needed to improve the effectiveness of prevention and treatment of respiratory tract infections. The implications of this study are expected to be useful for future researchers and can be used in clinical applications
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Bassetti, S., Tschudin-Sutter, S., Egli, A., & Osthoff, M. (2022). Optimizing antibiotic therapies to reduce the risk of bacterial resistance. European Journal of Internal Medicine. https://doi.org/10.1016/j.ejim.2022.01.029
Issusilaningtyas E, Rochmah NN, Azmi SD, Fadhila N (2024). Effectiveness of Soursop Leaf Extract in Reducing Glucose Levels in Diabetes Mellitus Patients: Literature Study. Journal of Pharmacopoeia: Jurnal Farmasi. https://nawalaeducation.com/index.php/JP/article/view/558/1127
Bender, R., Sirota, S. B., Swetschinski, L., Dominguez, R.-M. V., Novotney, A., Wool, E., Ikuta, K., Vongpradith, A., Rogowski, E., Doxey, M., Troeger, C., Albertson, S., Jianing, He, J., Maass, K. L., A.F.Simões, E., Abdoun, M., Aziz, J. A., Abdulah, D. M., … Kyu, H. (2024). Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021. The Lancet. Infectious Diseases, 24, 974–1002. https://doi.org/10.1016/S1473-3099(24)00176-2
Blair, J., Webber, M., Baylay, A., Ogbolu, D., & Piddock, L. (2014). Molecular mechanisms of antibiotic resistance. Nature Reviews Microbiology, 13, 42–51. https://doi.org/10.1038/nrmicro3380
Boutzoukas, A. E., Mackow, N., Giri, A., Komarow, L., Hill, C., Chen, L., Doi, Y., Satlin, M. J., Arias, C., Wang, M., Moreo, L. M., Herc, E., Cober, E., Weston, G., Patel, R., Bonomo, R. A., Fowler, V., van Duin, D., Banerjee, R., … Zong, Z. (2024). Increased mortality in hospital- compared to community-onset carbapenem-resistant enterobacterales infections. Journal of Antimicrobial Chemotherapy, 79(11), 2916–2922. https://doi.org/10.1093/jac/dkae306
Chan, C., Tao, J., Chan, O., Li, H., & Pang, H. (2020). Preventing Respiratory Tract Infections by Synbiotic Interventions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Advances in Nutrition. https://doi.org/10.1093/advances/nmaa003
Chan, E. Y.-H., Yu, E. L. M., Angeletti, A., Arslan, Z., Basu, B., Boyer, O., Chan, C.-Y., Colucci, M., Dorval, G., Dossier, C., Drovandi, S., Ghiggeri, G. M., Gipson, D. S., Hamada, R., Hogan, J., Ishikura, K., Kamei, K., Kemper, M., Ma, A. L.-T., … Tullus, K. (2022). Long-term Efficacy and Safety of Repeated Rituximab to Maintain Remission in Idiopathic Childhood Nephrotic Syndrome: An International Study. Journal of the American Society of Nephrology, 33(6), 1193–1207. https://doi.org/10.1681/ASN.2021111472
Chen, T., Chen, G., Wang, G., Treeprasertsuk, S., Lesmana, C. R. A., Lin, H.-C., Al-mahtab, M., Chawla, Y. K., Tan, S.-S., Kao, J.-H., Yuen, M.-F., Lee, G.-H., Alcantara-Payawal, D., Nakayama, N., Abbas, Z., Jafri, W., Kim, D.-J., Choudhury, A., Mahiwall, R., … Ning, Q. (2024). Expert consensus on the diagnosis and treatment of end-stage liver disease complicated by infections. Hepatology International, 18(3), 817–832. https://doi.org/10.1007/s12072-023-10637-3
Chua, A. Q., Verma, M., Villanueva, S. Y. A., Roxas, E., Hsu, L. Y., & Legido-Quigley, H. (2023). A Qualitative Study on the Implementation of the National Action Plan on Antimicrobial Resistance in Singapore. Antibiotics, 12(8). https://doi.org/10.3390/antibiotics12081258
Dass, A., Diaz-Cardona, Y., & Patel, S. (2023). 2619. Impact of Positive Real-Time Polymerase Chain Reaction Respiratory Viral Panel on the Duration of Antimicrobials. Open Forum Infectious Diseases, 10. https://doi.org/10.1093/ofid/ofad500.2232
Debes, S., Haug, J., De Blasio, B., Lindstrøm, J., Jonassen, C., & Dudman, S. (2023). Antibiotic Consumption in a Cohort of Hospitalized Adults with Viral Respiratory Tract Infection. Antibiotics, 12. https://doi.org/10.3390/antibiotics12040788
Derakhshan-Nezhad, E. (2023). An Overview of Bacterial Respiratory Tract Infections and their Etiologies. Journal of Medical Bacteriology. https://doi.org/10.18502/jmb.v11i1-2.14373
Feldman, C., & Richards, G. (2018). Appropriate antibiotic management of bacterial lower respiratory tract infections. F1000Research, 7. https://doi.org/10.12688/f1000research.14226.1
Feldman, C., & Shaddock, E. (2019). Epidemiology of lower respiratory tract infections in adults. Expert Review of Respiratory Medicine, 13, 63–77. https://doi.org/10.1080/17476348.2019.1555040
Harris, A., Hicks, L., & Qaseem, A. (2016). Appropriate Antibiotic Use for Acute Respiratory Tract Infection in Adults: Advice for High-Value Care From the American College of Physicians and the Centers for Disease Control and Prevention. Annals of Internal Medicine, 164, 425–434. https://doi.org/10.7326/M15-1840
Hawke, K., King, D., Van Driel, M., & Mcguire, T. (2022). Homeopathic medicinal products for preventing and treating acute respiratory tract infections in children. The Cochrane Database of Systematic Reviews, 12. https://doi.org/10.1002/14651858.cd005974.pub6
Huang, Y., Wei, W., Correia, D. F., Ming, B. H., Tang, A., Yeoh, E., Wong, S. Y. S., Ip, M., & Kwok, K. (2022). Antibiotic use for respiratory tract infections among the older adults living in long term care facilities: a systematic review and meta-analysis. The Journal of Hospital Infection. https://doi.org/10.1016/j.jhin.2022.09.016
Huemer, M., Shambat, S. M., Brugger, S., & Zinkernagel, A. (2020). Antibiotic resistance and persistence—Implications for human health and treatment perspectives. EMBO Reports, 21. https://doi.org/10.15252/embr.202051034
Jit, M., & Cooper, B. (2020). The role of vaccines in combating antimicrobial resistance. European Journal of Public Health. https://doi.org/10.1017/9781108864121.009
K, V. S., K, S., Jk, V., P, N., Y, R., & Y, P. C. (2024). A review on upper respiratory tract infection. Asian Journal of Hospital Pharmacy. https://doi.org/10.38022/ajhp.v4i4.93
Kandula, M., & Farrell, J. (2023). 867. Diagnostic test accuracy of TRAIL, IP-10 and C-RP biomarker combination (MeMed BV test) for discrimination of viral vs. bacterial infections among Emergency Department patients with febrile illness: A Systematic Review and Meta-analysis. Open Forum Infectious Diseases, 10. https://doi.org/10.1093/ofid/ofad500.912
King, D., Hawke, K., Mcguire, T., & Van Driel, M. (2020). Homeopathic preparations for preventing and treating acute upper respiratory tract infections in children: A systematic review and meta-analysis. Academic Pediatrics. https://doi.org/10.1016/j.acap.2020.07.016
Klugman, K., & Black, S. (2018). Impact of existing vaccines in reducing antibiotic resistance: Primary and secondary effects. Proceedings of the National Academy of Sciences, 115, 12896–12901. https://doi.org/10.1073/pnas.1721095115
Lazareva, N., & Rebrova, E. (2023). Advantages of instant forms of antibiotics in the treatment of lower respiratory tract infections. Meditsinskiy Sovet = Medical Council. https://doi.org/10.21518/ms2023-296
Legnani, D. (1997). Role of oral antibiotics in treatment of community-acquired lower respiratory tract infections. Diagnostic Microbiology and Infectious Disease, 27 1-2, 41–47. https://doi.org/10.1016/S0732-8893(97)00019-9
Lewnard, J., Lo, N., Arinaminpathy, N., Frost, I., & Laxminarayan, R. (2020). Childhood vaccines and antibiotic use in low- and middle-income countries. Nature, 581, 94–99. https://doi.org/10.1038/s41586-020-2238-4
Li, J., Kang-Birken, S., Mathews, S., Kenner, C., & Fitzgibbons, L. (2019). Role of rapid diagnostics for viral respiratory infections in antibiotic prescribing decision in the emergency department. Infection Control & Hospital Epidemiology, 40, 974–978. https://doi.org/10.1017/ice.2019.166
Lin, J., Nishino, K., Roberts, M., Tolmasky, M., Aminov, R., & Zhang, L. (2015). Mechanisms of antibiotic resistance. Frontiers in Microbiology, 6. https://doi.org/10.3389/fmicb.2015.00034
Lipsitch, M., & Siber, G. (2016). How Can Vaccines Contribute to Solving the Antimicrobial Resistance Problem? MBio, 7. https://doi.org/10.1128/mBio.00428-16
Machado-Duque, M., García, D. A., Emura-Vélez, M. H., Gaviria-Mendoza, A., Giraldo-Giraldo, C., & Machado-Alba, J. (2021). Antibiotic Prescriptions for Respiratory Tract Viral Infections in the Colombian Population. Antibiotics, 10. https://doi.org/10.3390/antibiotics10070864
Marra, A., De Almeida, S., Corrêa, L., Silva, M., Martino, M., Silva, C., Cal, R., Edmond, M., & Santos, O. Dos. (2009). The effect of limiting antimicrobial therapy duration on antimicrobial resistance in the critical care setting. American Journal of Infection Control, 37 3, 204–209. https://doi.org/10.1016/j.ajic.2008.06.008
Micoli, F., Bagnoli, F., Rappuoli, R., & Serruto, D. (2021). The role of vaccines in combatting antimicrobial resistance. Nature Reviews. Microbiology, 19, 287–302. https://doi.org/10.1038/s41579-020-00506-3
Mindt, B., & DiGiandomenico, A. (2022). Microbiome Modulation as a Novel Strategy to Treat and Prevent Respiratory Infections. Antibiotics, 11. https://doi.org/10.3390/antibiotics11040474
Mo, Y., Oonsivilai, M., Lim, C., Niehus, R., & Cooper, B. S. (2023). Implications of reducing antibiotic treatment duration for antimicrobial resistance in hospital settings: A modelling study and meta-analysis. PLoS Medicine, 20(6 June). https://doi.org/10.1371/journal.pmed.1004013
Montalbán-Hernández, K., Cogollo-García, A., De Velasco-Sada, P. G., Caballero, R., Casanovas, M., Subiza, J., & Conejero, L. (2024). MV130 in the Prevention of Recurrent Respiratory Tract Infections: A Retrospective Real-World Study in Children and Adults. Vaccines, 12. https://doi.org/10.3390/vaccines12020172
Mullins, L., Mason, E., Winter, K., & Sadarangani, M. (2023). Vaccination is an integral strategy to combat antimicrobial resistance. PLOS Pathogens, 19. https://doi.org/10.1371/journal.ppat.1011379
Munita, J., & Arias, C. (2016). Mechanisms of Antibiotic Resistance. Microbiology Spectrum, 4. https://doi.org/10.1128/microbiolspec.vmbf-0016-2015
Nwobodo, D. C., Ugwu, M., Anie, C. O., Al-Ouqaili, M., Ikem, J. C., Chigozie, U. V., & Saki, M. (2022). Antibiotic resistance: The challenges and some emerging strategies for tackling a global menace. Journal of Clinical Laboratory Analysis, 36. https://doi.org/10.1002/jcla.24655
Oladimeji, O., Cross, J., & Keathley-Herring, H. (2020). System dynamics applications in performance measurement research: progress and challenges. Management Decision. https://doi.org/10.1108/md-11-2019-1596
Papan, C., Argentiero, A., Porwoll, M., Hakim, U., Farinelli, E., Testa, I., Pasticci, M., Mezzetti, D., Perruccio, K., Etshtein, L., Mastboim, N., Moscoviz, E., Ber, T., Cohen, A., Simon, E., Boíco, O., Shani, L., Gottlieb, T., Navon, R., … Tenenbaum, T. (2021). A host signature based on TRAIL, IP-10, and CRP for reducing antibiotic overuse in children by differentiating bacterial from viral infections: A prospective, multicentre cohort study. Clinical Microbiology and Infection : The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases. https://doi.org/10.1016/j.cmi.2021.10.019
Raghav, H., Tayal, P., Das, R., & Mehta, D. (2022). Appropirate use of antibiotics for the management of respiratory tract infections. Infectious Disorders Drug Targets. https://doi.org/10.2174/1871526522666220118122516
Rice, L. (2008). The Maxwell Finland Lecture: for the duration-rational antibiotic administration in an era of antimicrobial resistance and clostridium difficile. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 46 4, 491–496. https://doi.org/10.1086/526535
Rousseau, G., Keijzers, G., van Meer, O., Craig, S., Karamercan, M., Klim, S., Body, R., Kuan, W. S., Harjola, V.-P., Jones, P., Verschuren, F., Holdgate, A., Christ, M., Golea, A., Capsec, J., Barletta, C., Graham, C. A., Garcia-Castrillo, L., Laribi, S., & Kelly, A.-M. (2021). Epidemiology, treatment and outcome of patients with lower respiratory tract infection presenting to emergency departments with dyspnoea (AANZDEM and EuroDEM studies). EMA - Emergency Medicine Australasia, 33(1), 58–66. https://doi.org/10.1111/1742-6723.13567
Sécher, T., Mayor, A., & Heuzé-Vourc’h, N. (2019). Inhalation of Immuno-Therapeutics/-Prophylactics to Fight Respiratory Tract Infections: An Appropriate Drug at the Right Place! Frontiers in Immunology, 10. https://doi.org/10.3389/fimmu.2019.02760
See, K. C., & Lau, Y. H. (2023). Acute management of pneumonia in adult patients. Singapore Medical Journal, 64(3), 209–216. https://doi.org/10.4103/singaporemedj.SMJ-2022-050
Shahanenko, R., Kozii, N., Shahanenko, V., Avramenko, N., & Taranuha, S. (2023). Influence of antibiotic treatment duration on the development of antibiotic resistance. Naukovij Vìsnik Veterinarnoï Medicini. https://doi.org/10.33245/2310-4902-2023-180-1-113-124
Singh, S. (2016). Respiratory Viral Infections. Seminars in Respiratory and Critical Care Medicine, 37, 485–486. https://doi.org/10.1055/s-0036-1584802
Sirota, S. B., Doxey, M., Dominguez, R.-M. V., Bender, R., Vongpradith, A., Albertson, S., Novotney, A., Burkart, K., Carter, A., Abdi, P., Abdoun, M., Abebe, A., Abegaz, K. H., Aboagye, R., Abolhassani, H., Abreu, L. G., Abualruz, H., Abu-Gharbieh, E., Aburuz, S., … Kyu, H. (2024). Global, regional, and national burden of upper respiratory infections and otitis media, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021. The Lancet. Infectious Diseases, 25, 36–51. https://doi.org/10.1016/s1473-3099(24)00430-4
Smith, O. (2021). Vaccines and antibiotic resistance. Science. https://doi.org/10.1126/science.373.6556.754-f
Spellberg, B., & Rice, L. (2019). Duration of Antibiotic Therapy: Shorter Is Better. Annals of Internal Medicine, 171, 210–211. https://doi.org/10.7326/M19-1509
Stower, H. (2020). Vaccination combats antimicrobial resistance. Nature Medicine, 26, 822. https://doi.org/10.1038/s41591-020-0957-6
Sur, D., & Plesa, M. (2022). Antibiotic Use in Acute Upper Respiratory Tract Infections. American Family Physician, 106 6, 628–636. https://consensus.app/papers/antibiotic-use-in-acute-upper-respiratory-tract-sur-plesa/1b812dd7450054e1b7ac3ab40e5ff9ac/
Tambyah, P. A. (2021). Future role of vaccines on antibacterial resistance. International Journal of Antimicrobial Agents, 58. https://doi.org/10.1016/j.ijantimicag.2021.106420.44
Tan, R., Huang, Z., Guo, H., Weng, Y., & Chow, A. (2022). Antibiotic expectations of patients attending an emergency department with upper respiratory tract infections: clinical and behavioural determinants of antibiotic use. International Journal of Antimicrobial Agents, 59(2). https://doi.org/10.1016/j.ijantimicag.2021.106511
Tanday, S. (2016). Resisting the use of antibiotics for viral infections. The Lancet. Respiratory Medicine, 4 3, 179. https://doi.org/10.1016/S2213-2600(16)00060-6
Urban-Chmiel, R., Marek, A., Stępień-Pyśniak, D., Wieczorek, K., Dec, M., Nowaczek, A., & Osek, J. (2022). Antibiotic Resistance in Bacteria—A Review. Antibiotics, 11. https://doi.org/10.3390/antibiotics11081079
Villegas, G., Jauregui, L., Moreno, B., Nunez, H., & Kannan, S. (2021). Genesis of Antibiotic Resistance LXVIII: Effective Vaccination (Campaigns) Decrease Antibiotic Consumption Consequent Antibiotic‐Resistance (AR) Pandemic(ARP) – The exception that proves the rule. The FASEB Journal, 35. https://doi.org/10.1096/FASEBJ.2021.35.S1.02202
Walter, J., & Wunderink, R. (2017). Severe Respiratory Viral Infections: New Evidence and Changing Paradigms. Infectious Disease Clinics of North America, 31 3, 455–474. https://doi.org/10.1016/j.idc.2017.05.004
Yao, J., Zhao, J., Wen, J., Yang, Z.-J., Lin, Y.-P., Sun, L., Lu, Q., & Fan, G. (2022). Flavonoid-containing supplements for preventing acute respiratory tract infections: A systematic review and meta-analysis of 20 randomized controlled trials. Complementary Therapies in Medicine, 102865. https://doi.org/10.1016/j.ctim.2022.102865
Yu, X., Wang, H., Sheng, Chen, W., Sun, L., & Zou, Z. (2024). Estimating the global and regional burden of lower respiratory infections attributable to leading pathogens and the protective effectiveness of immunization programs. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 107268. https://doi.org/10.1016/j.ijid.2024.107268
Zhao, Y., Dong, B., & Hao, Q. (2022). Probiotics for preventing acute upper respiratory tract infections. The Cochrane Database of Systematic Reviews, 8. https://doi.org/10.1002/14651858.CD006895.pub4
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